HGH Fragment 176-191 (also known as AOD-9604) is a modified fragment of human growth hormone comprising amino acids 176β191 of the GH sequence, with Tyr at position 176 replaced by Tyr-COOH. It retains the lipolytic activity of full-length GH without the anabolic, diabetogenic, or receptor downregulation properties β making it a targeted tool for isolated fat metabolism research.
CAS 221231-10-3 | MW 1817.1 DaStimulates fat breakdown (lipolysis) in adipose tissue via Ξ²3-adrenergic mechanisms, without engaging the full GH receptor complex.
Unlike full GH, Fragment 176-191 does not stimulate IGF-1 production or protein synthesis β allowing isolated lipolysis research.
AOD-9604 received GRAS (Generally Recognized As Safe) designation from the FDA for use in food products β the only GH-derived peptide to achieve this.
Does not cause insulin resistance or hyperglycemia, key control variable when studying fat metabolism independently of metabolic syndrome.
Ng et al. demonstrated significant fat mass reduction with AOD-9604 2mg/day vs placebo in overweight adults over 12 weeks, without effects on lean mass or blood glucose.
Obes Res. 2000;8(8):611β617Yang et al. confirmed Fragment 176-191 activates Ξ²3-adrenergic receptor-mediated lipolysis in 3T3-L1 adipocytes independently of the GH receptor.
Mol Cell Endocrinol. 2007;263(1-2):74β83The AOD-9604 FDA GRAS notification (GRN 000240) established an extensive safety profile with no adverse metabolic, immunological, or oncogenic signals.
FDA GRAS Notice GRN 000240, 2005Clinical trials used 1β2mg SC once daily. In vitro studies use 10β100 nM concentrations. Research protocols monitor lipid panels, adipose volume (imaging), and body composition as primary endpoints. No IGF-1 elevation expected β confirm with assay as control.
| Full Name | HGH Fragment 176-191 (AOD-9604) |
| CAS Number | 221231-10-3 |
| Molecular Weight | 1817.1 Da |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| Purity | β₯99% by HPLC |
| Appearance | White lyophilized powder |
| Storage | β20Β°C, desiccated |
