AOD-9604 is a modified fragment of HGH (residues 176-191) with a Tyr substitution at position 176, designed to retain fat-burning properties while eliminating anabolic, diabetogenic, and receptor downregulation effects of full GH. It received FDA GRAS (Generally Recognized As Safe) designation and completed Phase II obesity trials, making it one of the most clinically validated peptides for isolated lipolysis research.
CAS 221231-10-3 | MW 1815.1 Da | FDA GRAS GRN 000240Stimulates lipolysis via Ξ²3-adrenergic receptor-mediated pathway in adipocytes β independent of GHR signalling.
Does not bind the GH receptor for anabolic signalling. IGF-1 levels remain unchanged β essential control variable for fat research.
No insulin resistance or hyperglycemia observed in Phase II trials β a key advantage over full GH in metabolic research.
Emerging data suggests AOD-9604 may stimulate cartilage repair via TGF-Ξ² independent of the GH axis β a secondary research application.
Ng et al. demonstrated significant fat mass reduction with AOD-9604 in obese adults over 12 weeks, with no adverse metabolic effects. Phase II safety and efficacy data are among the strongest for any lipolytic peptide.
Int J Obes. 2000;24(7):871β879The comprehensive safety dossier submitted for GRAS notification confirmed AOD-9604's safety profile across acute, subchronic, and genetic toxicology studies.
FDA GRAS Notice GRN 000240Investigational studies showed AOD-9604 stimulated chondrocyte proliferation and proteoglycan synthesis in osteoarthritis models β expanding beyond its lipolytic research profile.
Osteoarthritis Cartilage. 2014;22(1):S10βS11Phase II trials: 1mg (400Β΅g) - 9mg SC daily. Research protocols typically use 0.5β2mg ranges. In vitro adipocyte work: 10β100 nM. Endpoints: adipocyte size, lipid content (Oil Red O), lipolysis assay (glycerol release), body composition imaging.
| Full Name | AOD-9604 (Modified HGH Fragment 176-191) |
| CAS Number | 221231-10-3 |
| Molecular Weight | 1815.1 Da |
| FDA Status | GRAS GRN 000240 |
| Purity | β₯99% by HPLC |
| Appearance | White lyophilized powder |
| Storage | β20Β°C, desiccated |
