Lipo-C is a standardized research formulation combining Methionine, Inositol, Choline (MIC) and Methylcobalamin (B12). These compounds act as lipotropic agents — molecules that facilitate hepatic fat metabolism, support methyl group donation (methylation), and promote lipid transport from the liver. In research settings, Lipo-C is used to study hepatic lipid metabolism, NAFLD models, one-carbon metabolism, and body composition endpoints.
MIC + Methylcobalamin B12 | Research FormulationEssential methyl donor for SAM cycle — provides methyl groups for DNA, protein, and lipid methylation research endpoints.
IP3 second messenger precursor. Modulates insulin signalling, serotonin receptors, and hepatic lipid export via VLDL.
Required for VLDL assembly and hepatic fat export. Choline deficiency induces hepatic steatosis — key NAFLD model variable.
Cofactor for methionine synthase in the methylation cycle. Supports myelin synthesis and neurological research alongside metabolic endpoints.
Smith et al. demonstrated that choline deficiency in rodent diets induced hepatic steatosis and elevated ALT/AST, fully reversed by choline repletion — establishing choline as essential for NAFLD research models.
J Nutr Biochem. 2002;13(5):265–271Dinicola et al. showed myo-inositol supplementation improved insulin sensitivity, lipid profiles, and ovarian function in PCOS models — demonstrating inositol's multi-system metabolic effects.
Int J Endocrinol. 2017;2017:7989054Comprehensive review of the SAM methylation cycle confirms methionine as the rate-limiting one-carbon donor for epigenetic and metabolic research protocols.
Annu Rev Nutr. 2018;38:265–290Rodent lipotropic studies: 0.1–1 mL/day SC. Components in published research: Methionine 50–100 mg, Inositol 50–100 mg, Choline 25–50 mg, B12 1–5 mg per dose. In vitro hepatocyte studies use individual component concentrations in physiological ranges. Endpoints: hepatic lipid content (Oil Red O), VLDL production, ALT/AST, SAM/SAH ratio.
| Components | Methionine · Inositol · Choline · Methylcobalamin (B12) |
| Format | Sterile multi-dose vial |
| Purity (components) | ≥99% by HPLC |
| Appearance | Clear to pale yellow solution |
| Storage | 4°C, protect from light |
| Application | Hepatic lipid, methylation, metabolic research |
