Delta Sleep Inducing Peptide (DSIP) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood by Monnier et al. in 1977. It is studied for its role in sleep architecture modulation, HPA axis regulation, antioxidant activity, and stress attenuation. Endogenous DSIP is found in the hypothalamus, limbic system, and pituitary.
CAS 62568-57-4 | MW 848.9 DaPublished research shows DSIP can shift EEG patterns toward delta-wave sleep in rodent models, supporting its name and proposed CNS role.
DSIP attenuates ACTH and cortisol responses to stress stimuli, suggesting a buffering role in the HPA stress axis.
In vitro studies demonstrate DSIP scavenges reactive oxygen species and upregulates antioxidant enzymes in neuronal cell lines.
Evidence suggests DSIP interacts with opioid receptors, potentially contributing to pain modulation and anxiolytic endpoints.
Monnier et al. (1977) isolated DSIP from the cerebral venous blood of sleep-deprived rabbits and demonstrated its ability to induce delta-wave sleep when injected into waking recipients.
Experientia. 1977;33(4):548–552Graf and Kastin showed DSIP attenuated corticosterone responses to environmental stress in rats and reduced behavioral stress markers across multiple paradigms.
Neurosci Biobehav Rev. 1984;8(1):83–93Popovic et al. demonstrated DSIP significantly reduced lipid peroxidation and improved antioxidant enzyme activity in brain tissue oxidative stress models.
Ann N Y Acad Sci. 2002;962:438–443Published rodent studies use 0.5–5 nmol/kg IV. Sleep EEG studies typically administer DSIP during the dark phase. In vitro neuroprotection studies use 10–1000 nM concentration ranges. HPA axis studies measure ACTH, cortisol, and corticosterone as primary endpoints alongside sleep metrics.
| Full Name | Delta Sleep Inducing Peptide (DSIP) |
| CAS Number | 62568-57-4 |
| Molecular Formula | C₃₅H₄₈N₁₀O₁₅ |
| Molecular Weight | 848.9 Da |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Purity | ≥99% by HPLC |
| Storage | −20°C, desiccated |
