Thymalin (Glu-Trp) is a synthetic dipeptide based on thymus gland extract fractions, developed by Prof. Vladimir Khavinson. The thymus gland is central to T-cell maturation and immune surveillance, but involutes with age. Thymalin research focuses on immune system restoration in aging and immunosuppressed models β restoring T-cell populations, NK cell activity, and thymic peptide hormone levels.
CAS 67984-60-5 | MW 333.4 Da | Glu-TrpPublished studies show Thymalin increases CD4+ and CD8+ T-cell counts in aged and immunosuppressed rodent models.
Natural killer cell cytotoxicity is restored toward younger-animal baselines after Thymalin treatment in aged models.
Thymalin stimulates thymosin-like immunomodulatory activity, partially compensating for age-related thymic involution.
T-cell proliferative responses and IL-2 production increase after Thymalin administration β key immune research endpoint.
Morozov et al. demonstrated Thymalin administration to elderly subjects restored T-cell function and NK cell activity toward younger-subject baselines over 6 months of treatment.
Gerontology. 2000;46(3):133β142Anisimov et al. showed Thymalin extended mean lifespan by 12β17% in aging rodent models and reduced cancer incidence β among the strongest peptide longevity data in literature.
Ann N Y Acad Sci. 2005;1057:297β307Thymalin restored immune parameters faster in immunosuppressed post-surgical patients compared to controls β proposing utility in immune recovery research.
Bull Exp Biol Med. 2003;136(1):20β23Published human and rodent studies use 5β20 mg/day SC or IM for 10-day cycles. Typical research cycle: 10 days per quarter. Endpoints: lymphocyte subset counts (CD3, CD4, CD8, NK), IL-2 production assay, natural killer cytotoxicity assay, and thymulin levels. Compare to control (age-matched untreated animals).
| Full Name | Thymalin (Glu-Trp) |
| CAS Number | 67984-60-5 |
| Molecular Formula | CββHββ NβOβ |
| Molecular Weight | 333.4 Da |
| Sequence | Glu-Trp |
| Origin | Thymus gland bioregulatory peptide |
| Purity | β₯99% by HPLC |
| Storage | β20Β°C, desiccated |
