Cerebrolysin is a standardized preparation of low-molecular-weight neuropeptides and amino acids derived from purified porcine brain proteins via enzymatic hydrolysis. It contains fragments with activity similar to endogenous neurotrophins (BDNF, NGF, CNTF). With over 50 years of clinical use in Europe and Asia and >600 published clinical/preclinical studies, it is one of the most researched neuropeptide formulations available.
Complex neuropeptide formulation | ~25% amino acids, ~75% peptidesPeptide fractions bind TrkB receptors to activate BDNF-like signalling pathways promoting neuronal survival and synaptic plasticity.
Studies show increased hippocampal neurogenesis and dendritic branching after Cerebrolysin treatment in aging and injury models.
Reduces glutamate excitotoxicity, calcium influx, and oxidative stress in ischemia models via multiple complementary mechanisms.
Preclinical data shows Cerebrolysin reduces amyloid-Ξ² aggregation and tau phosphorylation β mechanisms studied in Alzheimer's research models.
Muresanu et al. conducted a Phase IV randomized trial confirming Cerebrolysin reduced neurological deficit and improved functional outcomes in acute ischemic stroke at 30 and 90 days.
BMC Neurol. 2016;16:1β9Multiple double-blind trials showed Cerebrolysin treatment improved cognitive scores (ADAS-cog, MMSE) in mild-to-moderate Alzheimer's disease over 24 weeks.
J Neural Transm. 2015;122(10):1447β1457Shors et al. demonstrated that Cerebrolysin-treated aging rats showed significantly greater hippocampal neurogenesis than controls, with correlated improvements in spatial learning.
Eur J Pharmacol. 2007;568(1-3):36β44Clinical protocols: 10β30 mL IV infusion daily for 10β20 days. Research protocols: 2.5β5 mL/kg SC or IV in rodent models. Cognitive endpoints: Morris water maze, NOR, Y-maze. Neurochemical endpoints: BDNF/NGF ELISA, TrkB phosphorylation, BrdU neurogenesis assay, and amyloid/tau quantification.
| Type | Standardized porcine brain neuropeptide hydrolysate |
| Composition | ~25% amino acids, ~75% active peptides |
| Molecular Weight Range | <10,000 Da (all components) |
| Quality | Standardized batch testing |
| Appearance | Clear to pale yellow sterile solution |
| Storage | 4Β°C, protect from freezing |
